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        Menotrophin
        CAS No.: 9002-68-0 (Gonadotrophin; Treatment of infertility)

        Short Description:

        Source: Extracted from the urine of healthy pregnant women
        Function and use: For women, it can promote the maturation and ovulation of follicles, and maintain the function of the corpus luteum. For men, it can stimulate the development of Leydig cells, increase androgen secretion, promote testicular descent and the development of male secondary sexual characteristics. Combined with urinary gonadotropin, it can simulate the physiological peak of luteinizing hormone and induce ovulation. Clinically, chorionic gonadotropin is still the drug of choice for the treatment of menstrual disorders, anovulatory infertility, threatened abortion and habitual live birth, cryptorchidism, and male sexual dysfunction.

        Menotrophin-Pharmacopoeia?Standard:?BP


        Product Detail

        Product Tags

        CAS No.: 61489-71-2
        Complies with CP2020, USP43, BP2022

        Specification

        Menotrophin
        Source Menopausal woman urine
        Process description Menotrophin obtained from the urine of post-menopausal women, mainly contain follicle-stimulating hormone and luteinizing hormone.
        Manufacturing requirements This product should be extracted from healthy human urine. The production process should conform with the requirements of current?version of?Good Manufacturing Practice. It needs to undergo appropriate technological methods for virus safety control during the production process, so that any viruses such as hepatitis virus, human immunodeficiency virus, etc. can be removed or inactivated.

        Pharnacopoeia standard

        CP

        BP

        Character

        An almost white to?slightly yellow powder.Soluble in water. An almost white or slightly yellow powder.Soluble in water

        Identification

        Causes enlargement of the ovaries of immature female rats and increases the weight of the seminal vesicles and prostate gland of immature male rats when administered as directed in the Assay. Causes enlargement of the ovaries of immature female rats and increases the weight of the seminal vesicles and?prostate gland of immature male rats when administered as directed in the Assay.

        Test

        ResidualSolvent(ethanol) ≤0.5% ≤0.5%
        Water ≤5% Not more than 5.0%
        Abnormal toxicity Conform with regulation Conform with regulation
        Bacterial endotoxin ≤1EU/unit Not more than 0.78 IU per IU of FSH.

        Potency

        FSH Not less than 400IU/mg Not less than 40 IU/mg
        LH/FSH Approximately 1 Approximately 1

        Microbial limit

        TAMC ≤103?CFU/g ≤103?CFU/g
        TYMC ≤102?CFU/g ≤102?CFU/g

        Virus

        Hbs Ag Should be negative(10mg/ml) Should be negative(10mg/ml)
        HCV antibodies _________ Should be negative
        HIV I+II _________ Should be negative

        Storage

        Kept in an airtight, tamper-evident container and protected from light.?Preserved in cold place. Menotrophin should be kept in an airtight, tamper-evident container and protected from light.

        Category

        Gonadotropin drugs

        Preparation

        Menotrophin for injection

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