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        Kallidinogenase
        CAS No.: 9001-01-8 (kinin-releasing activity)

        Short Description:

        Source: Extracted from porcine pancreas
        Function and use:Kallidinogenase is a kind of kallikrein in human tissues and mammals. It exists in the body in the form of an inactive precursor—prekallikrein, which can degrade kininogen into kinin. Kinin can dilate blood vessels and capillaries,increase vascular permeability,improve microcirculation, regulate blood pressure, and reduce myocardial oxygen consumption. This enzyme is also an activating factor, which can activate plasminogen into plasmin, hydrolyze insoluble fibrin into soluble small peptides, thereby leading to thrombolysis, and can also regulate and reduce hypertension. For a variety of heart and cerebrovascular diseases, such as essential hypertension, arteriosclerosis, coronary atherosclerotic heart disease, cerebral arteriosclerosis, cerebral thrombosis, retinal blood supply disorders and peripheral vascular disease.

        Kallidinogenase-Pharmacopoeia?Standard:?JP


        Product Detail

        Product Tags

        CAS No.: 9001-01-8
        Complies with CP2020,?JP18

        Specification

        Kallidinogenase

        Source Porcine pancreas
        Process description Kallidinogenase is an enzyme extracted from healthy porcine pancreas, and has kinin-releasing activity based on cleavage of kininogen. It contains not less than 300 kallidinogenase units(for oral use) or 600 kallidinogenase units(for injection use) per mg
        Productionrequirements This product should be extracted from porcine pancreas that has passed quarantine. Production process should conform with the requirements of current version of Good Manufacturing Practice. This product is derived from animals, and appropriate virus inactivation processes should be used for virus safety control during production

        Pharmacopoeia standard

        CP

        JP

        for oral

        for injection

        Character

        White or almost white powder. Odorless.It is freely soluble in water, and practically insoluble in ethanol and diethyl ether. Description Kallidinogenase occurs as a white to light brown powder. It is odorless or has a faint, characteristic It is freely soluble in water, and practically insoluble in ethanol (95) and in diethyl ether.

        Identification

        The value of R?should be 0.12~0.17 The value of R does not exceed 0.2
        The retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution the value of R is between 0.12~0.16

        Test

        pH 5.5-7.5 5.5-7.5
        Appearance of solution Should be clear _______
        Purity ≥70% ≥90% _______
        Purity Fat The mass of residue is not more than 5mg The mass of residue is not more than 1mg
        Kininase _______ The value R is not less than 0.8
        Trypsin-like substance _______ The value of T does not exceed 0.05
        Protease A280≤0.2 The value of (A-A0) not more than 0.2
        Loss on drying ≤5.0% Not more than 2.0%
        Residue on ignition ≤3.0% Not more than 3%
        Bacterial endotoxin / ≤2.5 EU/IU(for injection) _______
        Kinin-releasing activity _______ Not less than 500ng bradykinin equivalent/minute/unit
        Total protein Conform with regulation _______

        Potency

        Enzyme activity Conform with regulation Not less than 25IU/mg
        Specific activity ≥300IU/mg.pr ≥?600IU/mg.pr Not less than 100IU/mg.pr

        Microbial limit

        TAMC ≤1000cfu/g ≤1000cfu/g
        TYMC ≤100cfu/g ≤100cfu/g
        Escherichia coli Should not be detected per g Should not be detected per g
        Salmonella Should not be detected per 10g Should not be detected per 10g

        Storage

        Protected from light, sealed, stored in a cool, dry place. Tight containers

        Category

        Vasodilators.

        Preparation

        Kallidinogeanse?enteric-coated tablets

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